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Glutarimide

Glutarimide, also known by its chemical name2,6-piperidinedione, is the organic compound with the formula (CH2)3(CO)2NH It is a white solid compound that forms upon dehydration of the amide of glutaric acid.[2]

The drug lenalidomide contains the substructure glutarimide (blue)

Glutaramide is at the core of numerous medical drugs and substances, including lenalidomide (a medication used to treat anemia and multiple myeloma;[3] and cycloheximide, a potent inhibitor of protein synthesis.[4] along with fluoxetine (an SSRI), as well as the sedative/"tranquilizer" (tranquilizer)-hypnotic drugs: glutethimide (branded Doriden to 1993 (in US) and 2006 (in Hugary)and aminoglutethimide.

References

  1. ^ Glutarimide - Sigma-Aldrich
  2. ^ Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. (1957). "Glutaric Acid and Glutarimide". Organic Syntheses. 37: 47. doi:10.15227/orgsyn.037.0047.
  3. ^ "A to Z List of Cancer Drugs: Lenalidomide". National Cancer Institute. 1 September 2022. Retrieved 5 August 2024.
  4. ^ Sisler, Hugh D.; Siegel, Malcolm R. (1967). "Cycloheximide and Other Glutarimide Antibiotics". Mechanism of Action. pp. 283–307. doi:10.1007/978-3-642-46051-7_21. ISBN 978-3-642-46053-1.