Memantine/donepezil
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type.[1] It contains memantine hydrochloride (it acts as an NMDA receptor antagonist, among various other types of targets like 5-HT3 receptor, Nicotinic acetylcholine receptor, and Sigma-1 receptor) and donepezil hydrochloride, which is an acetylcholinesterase inhibitor.[1] It is taken by mouth.[1]
Memantine/donepezil was approved for medical use in the United States in 2014.[3]
References
- ^ a b c d "Namzaric- memantine hydrochloride and donepezil hydrochloride capsule; Namzaric- memantine hydrochloride and donepezil hydrochloride kit". DailyMed. 22 January 2019. Archived from the original on 20 January 2022. Retrieved 22 December 2023.
- ^ "Periodic safety update report single assessment donepezil / memantine". European Medicines Agency. 7 March 2024. Retrieved 2 May 2024.
- ^ "Namzaric (memantine hydrochloride extended-release/donepezil hydrochloride) Capsules". U.S. Food and Drug Administration (FDA). 13 May 2015. Archived from the original on 22 December 2023. Retrieved 22 December 2023.
Further reading
- Calhoun A, King C, Khoury R, Grossberg GT (October 2018). "An evaluation of memantine ER + donepezil for the treatment of Alzheimer's disease". Expert Opinion on Pharmacotherapy. 19 (15): 1711–1717. doi:10.1080/14656566.2018.1519022. PMID 30244611. S2CID 52336224.
