2008 U.S. Men's Clay Court Championships – Singles

Ivo Karlović was the defending champion, but chose not to participate that year.

Seventh-seeded Marcel Granollers Pujol won in the final 6–4, 1–6, 7–5, against James Blake.

	Semifinals							Final
	1	James Blake	6	7
	8	Óscar Hernández	3	63
								1	James Blake	4	6	5
								7	Marcel Granollers Pujol	6	1	7
	7	Marcel Granollers Pujol	3	7	6
		Wayne Odesnik	6	5	3

	First round							Second round							Quarterfinals							Semifinals
	1	J Blake	6	6
	WC	K Nishikori	4	4				1	J Blake	6	6
	Q	R Harrison	6	6				Q	R Harrison	3	2
		P Cuevas	4	3											1	J Blake	6	6
		P Capdeville	6	6											5	A Calleri	4	3
	Q	D Hartfield	0	4					P Capdeville	2	1
		V Spadea	4	3				5	A Calleri	6	6
	5	A Calleri	6	6																		1	J Blake	6	7
	3	M Fish	7	6																		8	Ó Hernández	3	63
		R Schüttler	64	3				3	M Fish	6	6
		C Berlocq	3	6	5			WC	H Armando	3	2
	WC	H Armando	6	4	7										3	M Fish	2	65
	Q	F Vicente	3	65											8	Ó Hernández	6	7
		D Young	6	7					D Young	4	4
		JP Brzezicki	6	3	2			8	Ó Hernández	6	6
	8	Ó Hernández	3	6	6

	First round							Second round							Quarterfinals							Semifinals
	7	M Granollers Pujol	6	6
		E Gulbis	2	0				7	M Granollers Pujol	6	6
		P Luczak	6	6					P Luczak	3	2
	Q	H Levy	4	4											7	M Granollers Pujol	6	6
		V Troicki	3	4												M Daniel	3	2
		M Daniel	6	6					M Daniel	7	6
		N Massú	5	6	6				N Massú	63	2
	4	S Querrey	7	4	4																	7	M Granollers Pujol	3	7	6
	6	D Sela	7	6																			W Odesnik	6	5	3
		R Ginepri	65	2				6	D Sela	3	5
		W Odesnik	6	6					W Odesnik	6	7
	WC	A Delić	3	3												W Odesnik	2	7	6
		S Roitman	3	7	6											S Roitman	6	64	1
		J Isner	6	66	3				S Roitman	6	7
		I Kunitsyn	5	6	6				I Kunitsyn	3	63
	2	T Haas	7	4	4

• Draw
• Qualifying draw